GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs12220777 | 1 | rs12220777 | chr10:81788104 | LOC219347 | chr10:81805991-81838949:- | -0.36 | -4.42 | 1.29E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| BLCA | cis | rs12220238 | 1 | rs12252705 | chr10:75984863 | ADK | chr10:75910965-76469059:+ | 0.28 | 4.36 | 1.66E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs12256105 | chr10:75909634 | ADK | chr10:75910965-76469059:+ | 0.28 | 4.37 | 1.58E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs9783347 | 1 | rs12286683 | chr11:18348662 | GTF2H1 | chr11:18343816-18388590:+ | 0.31 | 6 | 4.7E-9 | Pancreatic cancer |
| BLCA | cis | rs7980687 | 1 | rs12299125 | chr12:123862447 | CDK2AP1 | chr12:123745542-123756687:- | -0.37 | -5.17 | 3.82E-7 | Educational attainment;Height;Head circumference (infant) |
| BLCA | cis | rs2832077 | 1 | rs12329875 | chr21:30137796 | N6AMT1 | chr21:30244513-30257693:- | -0.29 | -4.78 | 2.53E-6 | Cognitive test performance |
| BLCA | cis | rs12220238 | 1 | rs12355771 | chr10:75894404 | ADK | chr10:75910965-76469059:+ | 0.27 | 4.02 | 6.95E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs7923609 | 1 | rs12355784 | chr10:65121565 | NRBF2 | chr10:64893007-64914785:+ | -0.23 | -4.35 | 1.72E-5 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| BLCA | cis | rs12220238 | 1 | rs12357530 | chr10:75928654 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.47 | 1.02E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs12358614 | chr10:75906173 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.53 | 7.84E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs56322409 | 1 | rs12359272 | chr10:97365163 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.92 | 1.28E-6 | Blood metabolite levels |
| BLCA | cis | rs12220238 | 1 | rs12359456 | chr10:75937994 | ADK | chr10:75910965-76469059:+ | 0.32 | 4.75 | 2.93E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs12359456 | chr10:75937994 | AP3M1 | chr10:75880016-75910826:- | 0.31 | 3.98 | 8.08E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs7927771 | 1 | rs12361031 | chr11:47783076 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.58 | 4.59E-8 | Subjective well-being |
| BLCA | cis | rs7927771 | 1 | rs12363232 | chr11:47623890 | C1QTNF4 | chr11:47611216-47615961:- | -0.28 | -5.5 | 6.96E-8 | Subjective well-being |